*See savings card for details and instructions. Subject to availability. Patients who have prescription assistance through government insurers like Medicare or Medicaid are not eligible. Other restrictions apply.
Please see Important Safety Information and full
Prescribing Information.
Important Safety Information
ZYFLO CR
® is a leukotriene synthesis inhibitor indicated for the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older. Do not use ZYFLO CR
® to treat an acute asthma attack.
ZYFLO CR
® is contraindicated for patients with active liver disease or persistent hepatic function enzyme elevations

3 times the upper limit of normal. Assessment of hepatic function enzymes prior to and during ZYFLO CR
® therapy should be undertaken. ZYFLO CR
® is also contraindicated for patients with a history of allergic reactions to zileuton or any of the other ingredients.
The active ingredient in ZYFLO CR
® increases theophylline, warfarin, and propranolol levels. Dose adjustment of these other drugs and patient monitoring may be required. ZYFLO CR
® should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of liver disease. Neuropsychiatric events, including sleeping disorders and behavioral changes, may occur with ZYFLO CR
®.
The most common adverse reactions (
>5%) include: sinusitis, nausea, and pharyngolaryngeal pain.